Why Accelerate
There is a need to accelerate the process of evaluating innovative therapies and introduce them in standard cancer care in children and adolescents. Despite major progress over the last 50 years (80% of young people with malignancy are disease free at 5 years after diagnosis), cancer remains the most common cause of death by disease beyond the age of one. Medicines available for children with cancer are often off-patent, generic medicines which are prescribed off-label to paediatric patients. Even if cured, survivors suffer from long term side effects of treatment. 40% of childhood cancer survivors suffer from long term side effects that are impacting their lives severely. There is not only a need to cure more patients, but also cure them better.
Over the last 20 years, the landscape of drug development for children and adolescents has significantly changed, as result of regulatory initiatives in the US (RACE for children Act, passed in 2017 and into effect in 2020) and in Europe (The European Paediatric Medicine Regulation, 2006, and its current revision). Nevertheless, the number of new oncology drugs in pediatric development remains too low and more has to be done.
In addition, cancers in children differ from adult cancers. However, in pediatric oncology, needs are far from being addressed with too many developments of relevant oncology drugs in children being waived or significantly delayed.
ACCELERATE brings together academia, industry, advocacy and regulators to find solutions for more and better innovative therapies for children and adolescents with cancer
Our Name is our Mission
ACCELERATE engages with the international regulatory environments. ACCELERATE and its stakeholders believe following priorities in legislation are necessary to prosper childhood cancer drug development:
More information and details on ACCELERATE’s objectives have been described in following research paper: